Bottom Line: It is 100% safe to clear ARCHICAD AutoSave if you have saved and closed your active .pln architecture project.
What is the ArchiCAD AutoSave Folder?
Located at %LocalAppData%\Graphisoft\ARCHICAD AutoSave on Windows (or ~/Library/Application Support/GRAPHISOFT/ARCHICAD AutoSave on Mac), ArchiCAD caches temporary project recovery files.
How to Delete ArchiCAD AutoSave
rmdir /s /q "%LocalAppData%\Graphisoft\ARCHICAD AutoSave"
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