Bottom Line: It is 100% safe to clear Sublime Text cache. Sublime Text uses this directory to store compiled syntax definitions (.cache).
What is Sublime Text Cache?
Located at %AppData%\Sublime Text\Cache (or ~/Library/Caches/Sublime Text), Sublime Text caches syntax highlighting definitions and project symbol indexes.
How to Clear Sublime Text Cache
rmdir /s /q "%AppData%\Sublime Text\Cache"
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